Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Saralasin TFA | 34273-10-4 | 99.18% | 1026.07 | 25 MG
Saralasin TFA, an octapeptide analog of angiotensin II, functions as a competitive angiotensin II receptor antagonist and exhibits partial agonist activity. It is utilized in the research of renovascular hypertension and renin-dependent (angiotensinogenic) hypertension.
- Competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM.
- Exhibits partial agonist activity.
- Inhibits cell growth in 3T3 and SV3T3 cells.
- Restores potassium currents in myocytes.
- Inhibits binding of FITC-Ang II to rat liver membrane preparation.
- Reduces ovulation rate and prostaglandin levels in vitro.
- Ameliorates oxidative stress and tissue injury in cerulein-induced pancreatitis in rats.
- Increases serum renin activity in normal, conscious rats.
Medchemexpress LLC Huwentoxin-IV TFA | 526224-73-7 | 4106.78 | 100 UG
Huwentoxin-IV is a potent and selective sodium channel blocker that inhibits neuronal Nav1.7, Nav1.2, Nav1.3, and Nav1.4. It preferentially blocks the peripheral nerve subtype Nav1.7 by binding to neurotoxin receptor site 4. This compound has demonstrated analgesic effects in animal models of inflammatory and neuropathic pain. Its molecular weight is 4106.78, with a chemical formula of C174H278N52O51S6.
- Inhibits Nav1.7 with an IC50 of 26 nM
- Inhibits Nav1.2 with an IC50 of 150 nM
- Inhibits Nav1.3 with an IC50 of 338 nM
- Inhibits Nav1.4 with an IC50 of 400 nM
- Features sequence: Glu-Cys-Leu-Glu-Ile-Phe-Lys-Ala-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ss-Lys-Leu-Val-Cys-Ser-Arg-Lys-Thr-Trp-Cys-Lys-Tyr-Gln-Ile-NH2
- Includes disulfide bridges: Cys2-Cys17; Cys9-Cys24; Cys16-Cys31
Medchemexpress LLC Ebiratide TFA | 99.0% | 996.23 | 5 MG
Ebiratide TFA (HOE-427) is an ACTH 4-9 derivative that acts directly on the central nervous system and shows memory-enhancing effects. It increases acetylcholine (ACh) metabolism in the rat brain. Ebiratide TFA has neuroprotective efficacy in mice models with electroconvulsive shock and Scopolamine-induced memory impairment, demonstrating anti-amnestic efficacy.
- ACTH 4-9 derivative.
- Acts directly on the central nervous system.
- Exhibits memory-enhancing efficacy.
- Enhances acetylcholine (ACh) metabolism in rat brain.
- Exhibits neuroprotective and anti-amnestic efficacy in animal models.
Medchemexpress LLC DV1 TFA | 98.5% | 2424.85 | 5 MG
DV1 TFA is a selective antagonist for CXC chemokine receptor 4 (CXCR4) and exhibits antiviral activity. This product is for research use only and has not been fully validated for medical applications.
- Selective antagonist for CXC chemokine receptor 4 (CXCR4)
- Exhibits antiviral activity
- For research use only
Medchemexpress LLC Spexin (Neuropeptide Q) | 1370290-58-6 | >99.9% | 1619.88 | 5 MG
Spexin (Neuropeptide Q) | 1370290-58-6 | >99.9% | 1619.88 | 5 MG
TARGETMOL CHEMICALS INC Atecegatran TFA 1MG
Also available in 5 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Atecegatran TFA is often used as an anticoagulant and can be used to treat cardiovascular disease. Purity 98.5%
Medchemexpress LLC BTR2000 TFA | 99.0% | 764.83 | 5 MG
BTR2000 TFA is a specifically KLHL20 ligand that binds to the KLHL20 Kelch domain with high affinity. It can be utilized as a ligand for E3 ligase in the synthesis of BTR2004.
- Specifically targets KLHL20
- Binds to the KLHL20 Kelch domain with high affinity
- Useful as a ligand for E3 ligase
- Used for the synthesis of BTR2004
Medchemexpress LLC Cef20 TFA | 99.3% | 1057.19 | 5 MG
CEF20 TFA is an HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503). It is for research use only.
- An HLA-A*0201-restricted epitope from cytomegalovirus pp65 (495-503)
- For research use only
Medchemexpress LLC Gln-AMS TFA | 99.85% | 588.47 | 50 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It specifically inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. This product is intended for research use only.
- Inhibits glutaminyl-tRNA synthetase.
- High purity of 99.85%.
- Available in various quantities.
- Data sheet, COA, SDS, and handling instructions provided.
- Supported by customer reviews and publications.
Medchemexpress LLC Abaloparatide TFA | 99.5% | 4074.61 | 25 MG
Abaloparatide TFA | 99.5% | 4074.61 | 25 MG
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 5 MG
QL47B TFA is a biotinylated analogue of QL47 (HY-80003), functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It also exhibits anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM).
- Exhibits anti-tumor activity.
