Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Nangibotide TFA | 2014384-91-7 | 99.4% | 1457.46 | 25 MG
Nangibotide TFA | 2014384-91-7 | 99.4% | 1457.46 | 25 MG
Apexbio Technology LLC CGRP-RAT-TFA-1MG
CGRP (rat) TFA (CAS No 83651-90-5) is used in biomedical research particularly in the study of neuropeptides involved in pain and vasodilation pathways Originating from rat calcitonin gene-related peptide it interacts primarily with the CGRP receptor playing a role in the transmission of pain and regulation of vascular tone In vitro activities are typically observable in the nanomolar to low micromolar range making it suitable for mechanistic studies in cell-based assays and functional experiments This compound is widely applied in cell models to investigate neuronal signaling and is also used in animal studies to understand migraine pathophysiology and vasodilation mechanisms Additionally it serves as a tool in drug screening particularly for the development of migraine therapeutics Experimental concentrations typically depend on the specific research design
Medchemexpress LLC BIBP3226 TFA | 1068148-47-9 | 99.3% | 587.59 | 5 MG
BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Ki values of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. It has been observed to display an anxiogenic-like effect.
- Potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist.
- Ki values of 1.1 nM for rNPY Y1, 79 nM for hNPFF2, and 108 nM for rNPFF.
- Induces an anxiogenic-like effect at higher doses in vivo.
- Available in 5 mg quantity.
Medchemexpress LLC Cyclo(Arg-Pro) TFA | 74838-83-8 | 98.6% | 367.32 | 5 MG
Cyclo(Arg-Pro) TFA is a chitinase inhibitor that disrupts cell separation and morphological transition of yeast by inhibiting chitinase activity. It prevents cell separation of *Saccharomyces cerevisiae*, leading to the formation of grape-like cell clusters, without inhibiting cell growth. Additionally, it blocks the morphological transition of *Candida albicans* from yeast form to hyphal form, without inhibiting cell growth.
- Disrupts cell separation and morphological transition of yeast
- Prevents cell separation of *Saccharomyces cerevisiae*
- Leads to formation of grape-like cell clusters
- Blocks morphological transition of *Candida albicans* from yeast form to hyphal form
Medchemexpress LLC CPP12 (TFA) | 98.7% | 1700.55 | 5 MG
CPP12 TFA is a small, amphiphilic, cyclic cell-penetrating peptide (CPP) in salt form. It binds directly to plasma membrane phospholipids, enters mammalian cells via endocytosis, and is then efficiently released from endosomes. This peptide can be used for intracellular delivery of drugs and chemical probes.
- Small, amphiphilic, cyclic cell-penetrating peptide
- Binds directly to plasma membrane phospholipids
- Enters mammalian cells via endocytosis
- Efficiently released from endosomes
- Used for intracellular delivery of drugs and chemical probes
Medchemexpress LLC L-Serine, L-alanyl-L-prolyl-L-prolyl-L-histidyl-L-alanyl-L-leucyl- (TFA) | 99.87% | 805.80 | 25 MG
RS 09 TFA is an LPS peptide mimic and a TLR4 agonist. It binds to TLR-4, activating NF-κB, and functions as an adjuvant in vivo to enhance the antigen-specific immune response.
- Acts as an LPS peptide mimic and TLR4 agonist.
- Binds to TLR-4 and activates NF-κB.
- Enhances antigen-specific immune response in vivo.
- Stimulates TLR-4 and activates NF-κB in HEK-BLUETM-4 cells.
- Induces nuclear translocation of NF-κB and secretion of inflammatory cytokines in RAW264.7 cells.
Medchemexpress LLC CRA-2059 TFA | 99.9% | 864.83 | 1 ML
CRA-2059 is a highly specific and selective tryptase inhibitor, with a Ki of 620 pM for recombinant human tryptase-β (rHTβ). Tryptase is a trypsin-like serine protease found as a major protein component in human mast cell secretory granules. CRA-2059 has the potential for inflammatory bowel disease research.
- Highly specific and selective tryptase inhibitor
- Potential for inflammatory bowel disease research
- Inhibits recombinant human tryptase-β (rHTβ) with a Ki of 620 pM
- Targets tryptase, a trypsin-like serine protease
Medchemexpress LLC K1 peptide TFA | 98.2% | 1489.59 (free acid) | 1 MG
K1 peptide TFA is a high-affinity peptide ligand for GABAA receptor-associated protein (GABARAP).
- High-affinity peptide ligand for GABAA receptor-associated protein (GABARAP)
- Solid appearance
- White to off-white color
- Target: GABA Receptor
- Pathway: Membrane Transporter/Ion Channel, Neuronal Signaling
- Powder storage: -80°C for 2 years, -20°C for 1 year
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Ncgc00138783 TFA | 00-00-0 | 99.4% | 617.62 g·mol⁻¹ | C28H27F4N7O3S | 5 MG
NCGC00138783 TFA is a small-molecule inhibitor that selectively targets the CD47/SIRPα immune checkpoint, blocking the CD47-SIRPα interaction with reported in vitro activity (IC50 ≈ 50 μM). Supplied as the trifluoroacetic acid (TFA) salt for research applications.
- Selective inhibitor of the CD47/SIRPα immune checkpoint.
- Reported IC50 approximately 50 μM in biochemical assays.
- Supplied as the trifluoroacetic acid (TFA) salt.
- High purity (99.4%).
- Molecular weight 617.62 g·mol⁻¹.
- Store at 4 °C; protect from moisture and light.
Medchemexpress LLC MIP-1095 trifluoroacetate | 00-00-0 | MFCD09802015 | 99.8% | 678.35 g/mol | C21H26F3IN4O10 | 5 MG
MIP-1095 trifluoroacetate is a small-molecule inhibitor of prostate-specific membrane antigen used for research and imaging probe development. The compound is supplied as a high-purity trifluoroacetate salt, suitable for radiolabeling and preclinical assays.
- Potent inhibitor of prostate-specific membrane antigen (PSMA).
- Provided as trifluoroacetate (TFA) salt for stability.
- High purity suitable for research applications.
- Compatible with radiolabeling for imaging probe development.
- Soluble in DMSO for assay preparation.
- Available in small-mass quantities for preclinical studies.
Medchemexpress LLC dTAGV-1 TFA | 2624313-15-9 | 99.9% | C70H91F3N6O16S | 1 MG
dTAGV-1 TFA is a potent and selective PROTAC degrader targeting FKBP12F36V-tagged proteins. It is capable of inducing degradation of FKBP12F36V-Nluc both in vitro in 293FT cells and in vivo in animal models.
- Potent and selective degrader of FKBP12F36V-tagged proteins.
- Induces degradation of FKBP12F36V-Nluc in vivo.
- Effective in 293FT cells.
- Reduces bioluminescent signal in animal models.
Medchemexpress LLC HsTX1 TFA | 99.2% | 3818.47 | 1 MG
HsTX1 TFA toxin, derived from the scorpion *Heterometrus spinnifer*, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. It acts as an inhibitor of the potassium channel.
- Inhibits Kv1.3 potassium channels with an IC50 of 12 pM
- Inhibits TEM cell activation
- Attenuates inflammation in autoimmunity